Dr. Moti Kashyap directs the Atherosclerosis Research program at the Long Beach VA Medical Center and is Professor of Medicine at University of California, Irvine. He is a physician-scientist who combines clinical investigation with basic research.
Basic research is currently focused on High Density Lipoprotein (HDL) metabolism and newer HDL based therapies. His group has defined, at the cellular and molecular level, the mechanism of action of several clinically used drugs for dyslipidemia. These findings have paved the way for assessing newer therapies for atherosclerosis.
Moti Kashyap, MD
Highlights of recent findings include demonstration that a 22 amino-acid apolipoprotein AI mimetic peptide significantly reduces coronary and aortic root atherosclerosis in a mouse model. His laboratory is recognized internationally for research on niacin (nicotinic acid), which prevents heart attacks and stroke. He and his associates were the first to demonstrate the key enzyme and receptor, explaining how niacin lowers triglycerides and raises HDL. Identification of these sites of action has led to new drug discovery research.
Recent clinical investigation has focused major national/international trials to assess effects of therapeutic interventions for reducing cardiovascular disease (CVD) in elderly veterans. A completed study (VA HDL Intervention Trial) showed that increasing HDL with gemfibrozil significantly reduced CVD. Other major ongoing clinical trials include a NIH funded study to determine whether lowering LDL and increasing HDL with a statin and niacin can reduce CVD more than lowering LDL with statin alone. Another VA funded study seeks to determine whether tight glucose control is associated with CVD protection in patients with diabetes mellitus. A new study will assess the effect of a novel potent HDL raising drug on CVD. Several other investigations are underway to assess new therapies for dyslipidemia and diabetes mellitus. The results of such studies have or will significantly change the practice of medicine, gerontology, cardiology and endocrinology.
Dr. Kashyap’s research work has been supported by numerous grants and has been published and lectured extensively. He is attending physician at the Cholesterol Clinic, which he founded at this medical center. He also attends patients in Geriatrics, Rehabilitation Medicine and Extended Care Healthcare group at this medical center, has served on several committees, and is peer reviewer for several journals.