Interests Sleep breathing disorders and endothelial dysfunction

Abstract My research interests is the vascular health implications of sleep apnea with an emphasis on mechanistic pathways. I am specifically interested in four areas within this larger domain:
1) The prediction of vascular outcomes in patients with sleep apnea;
2) The mechanistic pathways on the development of atherosclerotic health outcomes among patients with sleep apnea;
3) The impact of standard therapy for sleep apnea on reducing the risk for adverse cardiovascular and cerebrovascular outcomes; and
4) The metabolic consequences of sleep deprivation.

Publications Original Papers :

Jafari B., Mohsenin V, Endothelial dysfunction and hypertension in obstructive sleep apnea- Is it due to intermittent hypoxia? J Cardiovascular Dis Res 4 (2013) 87-91

Li P, Ghadersohi S, Jafari B, Teter B, Sazgar M. Characteristics of Refractory versus Medically-Controlled Epilepsy Patients with Obstructive Sleep Apnea and their Response to CPAP Treatment, Seizure, 2012 Nov;21(9):717-21.

Jafari B, Mohsenin V. Activation of Heme-Oxygenase and suppression of cGMP are associated with impaired Endothelial-Dependent Vasodilation in OSA with hypertention. Am J Hypertens 2012 Aug;25(8):854-61.
Jafari B., Mohsenin V, Overnight Rostral Fluid Shift in Obstructive Sleep Apnea: Does it affect the severity of Sleep-disordered Breathing? Chest 2011 Oct;140(4):991-7

Syrkina O, Jafari B, Hales CA, Quinn DA. Oxidant Stress Mediates Inflammation and Apoptosis in Ventilator-Induced Lung Injury. Respirology 2008 May;13(3):333-40.

Ouyang B, Guan X, Syrkina O, Jafari B, Quinn DA. Oxidant injury mediates TGF beta up-regulation in ventilator induced lung injury. Med J Chin PLA. 2006; 31(1): 18-21.

Jafari B, Hales CA, Quinn DA. Intracellular Glutathione, Role in Stretch-Induced Cytokine Release from Alveolar Type-2 like cells (A549) Respirology 2004; 9(1):43-53.

Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O, Bonventre JV, Hales CA. Systemic Microvascular Leak in an In Vivo Rat Model of Ventilator-induced Lung Injury. Am J Resp Crit Care Med 2003; 167(12): 1627-32.

Li LF, Ouyang B, Choukroun G, Matyal R, Mascarenhas M, Jafari B, Bonventre JV, Force T, Quinn DA. Stretch-Induced IL-8 depends on C-Jun N-Terminal and nuclear factor-{kappa}B-inducing kinases. Am J Physiol Lung Cell Mol Physiol 2003; 285(2): L464-75. Epub 2003 Apr 25.

Chapter Books and review Articles :

Jafari B. Portable home monitoring for Obstructive Sleep Apnea, Treatment Strategies – Respirator 2013; 4(1)

Jafari B, Mohsenin V. Obstructive Sleep Apnea, Stroke and Rehabilitation, Sleep, stroke and cardiovascular disease 2013

Jafari B, Mohsenin V. Polysomnography. Encyclopedia of Sleep ( 2013)

Jafari B, Roux F. Non-Positive Airway Pressure Therapy for Obstructive Sleep Apnea, Current Respiratory Care Reports 2012, 1: 111-122
Jafari B., Mohsenin V, Chapter 36: Clinical Case Studies II: Sleep-breathing Disorders. Review of Sleep Medicine 2011

Jafari B, Mohsenin V. Polysomnography. Clin Chest Med. 2010 Jun;31(2):287-297.

Societies American Thoracic Society (ATS)
American Academy of Sleep Medicine (AASM)

Other Experience Faculty Pulmonary & Critical Care Section
VAMCLB 2012—Pres

Post-doctoral research fellowship in Pulmonary and critical care medicine
Harvard University-MGH 1999

Graduate Programs Internal Medicine

Pulmonary Disease and Critical Care Medicine (IM)

Sleep Medicine

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Last updated 04/22/2014